Response to phorbol 13-acetate 12-myristate

Across TCGA patient cohorts, RNA activity of the Response to phorbol 13-acetate 12-myristate pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA12B, PRKD1_S249, and DDX47, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to phorbol 13-acetate 12-myristate activity versus HSPA12B in OV (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HSPA12B →	+0.367	+0.048	.005	.001	3	5
OV	PRKD1_S249 →	+0.803	+0.059	.001	<.001	3	5
BRCA	DDX47 →	-0.244	-0.034	.001	.001	3	5
BRCA	RPL7L1 →	-0.380	-0.054	.002	<.001	3	5
LSCC	DDX18 →	-0.333	-0.050	<.001	<.001	3	5
UCEC	FBP1 →	+0.622	+0.083	.005	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904627 vs HSPA12B — OV

Explore this scatter interactively →