Response to phorbol 13-acetate 12-myristate

Across TCGA patient cohorts, RNA activity of the Response to phorbol 13-acetate 12-myristate pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELN, PLPP4, and CLMAT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to phorbol 13-acetate 12-myristate activity versus ELN in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ELN →	+1.253	+0.608	.001	.004	3	5
PDAC	PLPP4 →	+0.852	+0.685	<.001	<.001	3	5
PDAC	CLMAT3 →	+0.403	+0.860	.001	<.001	3	4
PDAC	SUGCT →	+0.825	+0.967	<.001	<.001	3	4
BRCA	MYL9 →	+0.717	+0.611	.001	.001	3	4
PDAC	SPARC →	+0.648	+0.787	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904627 vs ELN — BRCA

Explore this scatter interactively →