Response to phorbol 13-acetate 12-myristate

Across TCGA cell cohorts, RNA activity of the Response to phorbol 13-acetate 12-myristate pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTBN1, FAM98A, and CRACD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTBN1 grouped by Response to phorbol 13-acetate 12-myristate-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPTBN1 →	-0.910	-1.060	.009	.006	3	4
STOMACH	FAM98A →	+0.585	+0.913	.002	.007	3	4
STOMACH	CRACD →	-1.840	-1.390	.006	.002	3	4
PANCREAS	WWC1 →	-1.373	-1.058	.001	.004	3	4
BREAST	BCAS1 →	-2.644	-0.983	.004	.003	3	4
LIVER	NFIL3 →	+0.961	+1.541	.006	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTBN1 by Response to phorbol 13-acetate 12-myristate activity — OVARY

Explore this box plot interactively →