L-alanine transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-alanine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC1A4, SLC3A2, and SLC7A8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-alanine transmembrane transport activity versus SLC1A4 in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC1A4 →	+0.892	+0.106	<.001	<.001	3	5
GBM	SLC3A2 →	+0.326	+0.071	<.001	.006	3	5
BRCA	SLC7A8 →	+1.252	+0.171	<.001	<.001	3	5
LUAD	SLC38A5 →	+0.834	+0.058	<.001	.006	3	4
GBM	ATP2B1 →	+0.273	+0.084	.001	.003	3	4
LUAD	BASP1_T36 →	+0.812	+0.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904557 vs SLC1A4 — BRCA

Explore this scatter interactively →