L-alanine transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-alanine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A4, NDRG4, and SGMS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-alanine transmembrane transport activity versus SLC1A4 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC1A4 →	+0.829	+0.422	<.001	<.001	3	5
LSCC	NDRG4 →	+1.297	+0.425	<.001	.001	3	4
GBM	SGMS2 →	-0.613	-0.355	.001	.009	3	4
LSCC	GINS3 →	+0.791	+0.452	<.001	.001	3	4
BRCA	SLC26A6 →	+0.452	+0.220	.001	.006	3	3
BRCA	MIR4652 →	-0.166	-0.678	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904557 vs SLC1A4 — BRCA

Explore this scatter interactively →