Positive regulation of TORC2 signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of TORC2 signaling pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APBB1IP, DAB2, and SAMHD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of TORC2 signaling activity versus APBB1IP in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	APBB1IP →	+0.550	+0.060	<.001	.003	3	8
GBM	DAB2 →	+0.764	+0.096	<.001	<.001	3	8
HNSC	SAMHD1 →	+0.556	+0.097	<.001	<.001	3	7
GBM	WAS →	+0.475	+0.084	<.001	<.001	3	7
UCEC	WDFY4 →	+0.518	+0.145	<.001	<.001	3	7
LSCC	DOCK10 →	+0.529	+0.090	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904515 vs APBB1IP — OV

Explore this scatter interactively →