Positive regulation of TORC2 signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of TORC2 signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP9X, OTUD5, and CRABP2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP9X grouped by Positive regulation of TORC2 signaling-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	USP9X →	-0.628	-1.778	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	OTUD5 →	-0.371	-1.583	<.001	.002	3	10
OVARY	CRABP2 →	-0.202	-1.047	<.001	.008	2	5
LUNG_NSCLC_LUAD	LIFR →	-0.147	-0.714	.001	.007	2	5
BONE	VEGFA →	-0.415	-2.392	<.001	<.001	3	4
BONE	PTPN12 →	-0.212	-2.160	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP9X by Positive regulation of TORC2 signaling activity — PANCREAS

Explore this box plot interactively →