Positive regulation of TORC2 signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of TORC2 signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME7, LAMTOR1, and HABP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NME7 grouped by Positive regulation of TORC2 signaling-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NME7 →	-0.772	-0.625	<.001	.009	3	6
PANCREAS	LAMTOR1 →	-0.588	-1.603	.003	<.001	3	5
LIVER	HABP4 →	-1.278	-1.607	.002	<.001	3	5
LUNG_NSCLC_LUSC	ZDHHC2 →	-1.187	-1.491	.002	.002	3	5
LUNG_NSCLC_LUSC	STXBP1 →	-1.467	-1.551	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ARSK →	-0.888	-1.989	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NME7 by Positive regulation of TORC2 signaling activity — BREAST

Explore this box plot interactively →