Protein localization to ciliary transition zone

Across TCGA patient cohorts, RNA activity of the Protein localization to ciliary transition zone pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPPP3, SPAG9_S332, and NPHP4_S142, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to ciliary transition zone activity versus TPPP3 in UCEC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPPP3 →	+1.005	+0.063	<.001	<.001	3	7
UCEC	SPAG9_S332 →	-0.612	-0.059	.001	.002	3	6
UCEC	NPHP4_S142 →	+0.598	+0.080	<.001	<.001	3	6
UCEC	ARL6 →	+0.334	+0.066	.002	.001	3	6
UCEC	CROCC →	+0.485	+0.056	<.001	<.001	3	5
COAD	MS4A1_S36 →	-0.315	-0.042	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904491 vs TPPP3 — UCEC

Explore this scatter interactively →