Protein localization to ciliary transition zone

Across TCGA patient cohorts, RNA activity of the Protein localization to ciliary transition zone pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STPG1, SDHAF4, and GATA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to ciliary transition zone activity versus STPG1 in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STPG1 →	+0.384	+0.223	<.001	.001	3	5
LSCC	SDHAF4 →	+0.401	+0.260	.001	<.001	3	4
BRCA	GATA1 →	+0.354	+0.338	.005	<.001	3	3
LSCC	PACRG →	+0.356	+0.131	.009	.005	2	4
LSCC	LCA5 →	+0.717	+0.289	<.001	<.001	3	3
BRCA	ART5 →	+0.592	+0.280	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904491 vs STPG1 — LUAD

Explore this scatter interactively →