Protein localization to ciliary transition zone

Across TCGA cell cohorts, RNA activity of the Protein localization to ciliary transition zone pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFYA, PTBP2, and PLEKHO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFYA grouped by Protein localization to ciliary transition zone-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NFYA →	+0.650	+0.704	<.001	.001	3	5
BONE	PTBP2 →	+1.622	+1.750	.004	.001	3	4
STOMACH	PLEKHO1 →	+2.281	+0.557	<.001	<.001	3	4
STOMACH	SQOR →	-2.235	-0.489	<.001	.003	3	4
OVARY	PPM1G →	+0.604	+1.123	.002	.003	3	4
OVARY	RPL22 →	+0.353	+1.022	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFYA by Protein localization to ciliary transition zone activity — BREAST

Explore this box plot interactively →