Protein localization to ciliary transition zone

Across TCGA cell cohorts, RNA activity of the Protein localization to ciliary transition zone pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP2, FSTL1, and KIF7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to ciliary transition zone activity versus TIMP2 in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TIMP2 →	+1.466	+0.315	.006	.003	3	5
BREAST	FSTL1 →	+3.542	+0.216	.008	.001	2	5
LUNG_NSCLC_LUSC	KIF7 →	+2.806	+0.490	<.001	.006	3	4
OESOPHAGUS	KRCC1 →	+1.351	+0.273	.006	.002	3	4
OESOPHAGUS	UBOX5 →	+0.665	+0.236	.002	.006	3	4
LUNG_SCLC	BTG2 →	+1.996	+0.283	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904491 vs TIMP2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →