Regulation of intestinal absorption

Across TCGA patient cohorts, RNA activity of the Regulation of intestinal absorption pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D1, LPCAT3, and QKI, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intestinal absorption activity versus TBC1D1 in LUAD (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TBC1D1 →	-0.234	-0.085	<.001	.001	3	6
OV	LPCAT3 →	+0.595	+0.086	.003	.002	2	7
GBM	QKI →	-0.121	-0.497	.008	<.001	3	6
CCRCC	SH2B3_S150 →	-0.320	-0.101	<.001	<.001	3	6
LUAD	FKBP4 →	+0.470	+0.103	<.001	.001	3	5
LSCC	GRHL2 →	+0.405	+0.112	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904478 vs TBC1D1 — LUAD

Explore this scatter interactively →