Regulation of intestinal absorption

Across TCGA patient cohorts, RNA activity of the Regulation of intestinal absorption pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COA4, MRPL1, and FIBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intestinal absorption activity versus COA4 in OV (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COA4 →	-0.606	-0.281	<.001	<.001	3	5
UCEC	MRPL1 →	-0.489	-0.249	.002	<.001	3	4
COAD	FIBP →	-0.292	-0.111	.003	.009	3	4
UCEC	ENOPH1 →	-0.602	-0.217	<.001	<.001	3	4
UCEC	CCDC43 →	-0.520	-0.270	<.001	.005	3	4
GBM	HBA2 →	+1.673	+0.328	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904478 vs COA4 — OV

Explore this scatter interactively →