Regulation of intestinal absorption

Across TCGA cell cohorts, RNA activity of the Regulation of intestinal absorption pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUSC3, TGFB1, and ZNF613, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUSC3 grouped by Regulation of intestinal absorption-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TUSC3 →	-3.896	-1.830	.002	.002	3	5
STOMACH	TGFB1 →	-2.449	-1.450	<.001	<.001	3	4
STOMACH	ZNF613 →	-1.487	-1.332	<.001	.001	3	4
OESOPHAGUS	ZNF577 →	-1.804	-1.223	<.001	<.001	3	4
BREAST	DYNLRB1 →	-0.665	-0.990	.007	.001	3	4
BLOOD_Lymphoma	TXNDC15 →	-1.057	-1.251	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUSC3 by Regulation of intestinal absorption activity — LIVER

Explore this box plot interactively →