Regulation of t-circle formation

Across TCGA patient cohorts, RNA activity of the Regulation of t-circle formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLX4IP_S396, NUMA1_T2055, and PARN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of t-circle formation activity versus SLX4IP_S396 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLX4IP_S396 →	+0.475	+0.046	.008	<.001	3	6
LUAD	NUMA1_T2055 →	+0.668	+0.041	.009	.002	3	6
CCRCC	PARN →	+0.251	+0.049	<.001	<.001	3	6
HNSC	TNFRSF14 →	-0.631	-0.084	.006	.008	3	5
BRCA	DCTPP1 →	+0.538	+0.029	<.001	.003	3	5
LUAD	SLX4_S1453 →	+0.472	+0.057	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904429 vs SLX4IP_S396 — GBM

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