Regulation of t-circle formation

Across TCGA patient cohorts, RNA activity of the Regulation of t-circle formation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-597P, TBX19, and ZNF627, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of t-circle formation activity versus RNU6-597P in LUAD (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-597P →	-0.968	-0.512	<.001	.001	3	4
LUAD	TBX19 →	-0.379	-0.305	.002	.004	3	3
LUAD	ZNF627 →	-0.223	-0.369	.009	.001	3	3
LUAD	CNOT7P1 →	-0.224	-0.315	.003	.003	3	3
COAD	MARCHF7 →	-0.264	-0.711	.009	.004	3	3
COAD	CCDC126 →	-0.392	-0.831	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904429 vs RNU6-597P — LUAD

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