Regulation of t-circle formation

Across TCGA cell cohorts, RNA activity of the Regulation of t-circle formation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARA, ANAPC15, and IDH3B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of t-circle formation activity versus RARA in BREAST (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RARA →	-1.697	-0.147	.002	.006	3	3
BLOOD_Leukemia	ANAPC15 →	-0.694	-0.103	.009	<.001	3	3
STOMACH	IDH3B →	-0.909	-0.207	.003	.005	3	2
STOMACH	TMED10 →	+1.335	+0.207	.009	.005	3	2
BLOOD_Leukemia	RAG2 →	-2.781	-0.085	.001	.001	3	2
BLOOD_Myeloma	B4GALT6 →	-1.398	-0.124	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904429 vs RARA — BREAST

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