Negative regulation of tubulin deacetylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of tubulin deacetylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS9, TNFAIP8, and TPPP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tubulin deacetylation activity versus RPS9 in BRCA (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS9 →	-0.267	-0.062	.003	.005	3	6
BRCA	TNFAIP8 →	-0.383	-0.065	<.001	<.001	3	6
GBM	TPPP →	+1.036	+0.108	<.001	<.001	3	6
GBM	CASP4 →	-0.410	-0.084	<.001	<.001	3	6
BRCA	FRY →	+0.456	+0.069	<.001	<.001	3	6
GBM	HK3 →	-0.654	-0.060	.003	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904428 vs RPS9 — BRCA

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