Positive regulation of calcium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COBL, CFL2, and DLGAP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COBL grouped by Positive regulation of calcium ion transmembrane transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COBL →	-1.427	-0.587	.008	.008	3	5
LIVER	CFL2 →	+1.363	+0.336	.003	.002	3	5
SKIN	DLGAP5 →	+0.662	+0.970	.001	.002	3	4
SOFT_TISSUE	FAM8A1 →	-1.144	-1.245	<.001	.001	3	4
BREAST	ZBTB7B →	-0.968	-0.605	.005	.006	3	4
BREAST	TTC39A →	-2.579	-0.766	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COBL by Positive regulation of calcium ion transmembrane transport activity — BREAST

Explore this box plot interactively →