Positive regulation of calcium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A6, HPCAL1, and CAPN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transmembrane transport activity versus S100A6 in STOMACH (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	S100A6 →	+4.481	+0.393	.004	<.001	3	8
SKIN	HPCAL1 →	+2.497	+0.353	<.001	<.001	3	7
SKIN	CAPN2 →	+0.986	+0.298	<.001	<.001	3	7
BREAST	FOSL1 →	+3.843	+0.411	<.001	<.001	3	7
BLOOD_Leukemia	RALB →	+1.481	+0.239	<.001	.001	3	7
OESOPHAGUS	ASPH →	+1.867	+0.299	.007	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904427 vs S100A6 — STOMACH

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