Regulation of xenophagy

Across TCGA cell cohorts, RNA activity of the Regulation of xenophagy pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2L3, RNF148, and ZNF556, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2L3 grouped by Regulation of xenophagy-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UBE2L3 →	-0.700	-0.109	<.001	.003	3	4
BLOOD_Myeloma	RNF148 →	-0.766	-0.278	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZNF556 →	+1.413	+0.275	.001	<.001	3	4
SOFT_TISSUE	TMEM131L →	+1.110	+0.159	.003	.006	3	4
OVARY	DPYSL2 →	-1.372	-0.161	<.001	<.001	3	4
CNS	CHST11 →	-1.410	-0.168	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2L3 by Regulation of xenophagy activity — URINARY_TRACT

Explore this box plot interactively →