Positive regulation of protein localization to cell periphery

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to cell periphery pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, PRKG1, and HSPA12A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell periphery activity versus SEPTIN4 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	+0.597	+0.037	.002	.002	3	9
CCRCC	PRKG1 →	+0.492	+0.038	<.001	.001	3	9
GBM	HSPA12A →	+0.540	+0.032	.009	.001	3	8
OV	RPL5 →	-0.241	-0.039	<.001	.002	3	8
BRCA	ADD3 →	+0.390	+0.021	.001	<.001	3	8
BRCA	TNS2_S120 →	+0.477	+0.028	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904377 vs SEPTIN4 — GBM

Explore this scatter interactively →