Positive regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF6B, BTBD8, and GALC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATF6B grouped by Positive regulation of protein localization to cell periphery-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ATF6B →	+1.599	+0.307	<.001	.001	3	4
OESOPHAGUS	BTBD8 →	+1.212	+0.240	<.001	<.001	3	4
KIDNEY	GALC →	-1.407	-0.816	<.001	.003	3	3
PANCREAS	SRPRA →	+0.833	+0.281	.005	.002	3	3
LIVER	ADAM10 →	+0.775	+0.176	.001	.004	3	3
LIVER	CYB5R1 →	+0.810	+0.179	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATF6B by Positive regulation of protein localization to cell periphery activity — OESOPHAGUS

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