Positive regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, AKIRIN1, and BDNF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell periphery activity versus ITGA3 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITGA3 →	+5.641	+0.232	<.001	.009	3	6
LUNG_SCLC	AKIRIN1 →	-1.059	-0.170	.006	.001	3	5
LIVER	BDNF →	+2.043	+0.188	.006	.008	2	6
BONE	CASP4 →	+2.424	+0.163	.005	.002	3	5
SOFT_TISSUE	DAZAP2 →	+0.583	+0.286	.001	<.001	3	5
STOMACH	KLHL15 →	-1.324	-0.290	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904377 vs ITGA3 — LIVER

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