Negative regulation of protein localization to cell periphery

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF3C6P2, ZNF799, and RRM2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to cell periphery activity versus GTF3C6P2 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GTF3C6P2 →	-0.729	-0.123	.002	.001	3	4
UCEC	ZNF799 →	+0.407	+0.156	.002	.004	3	4
BRCA	RRM2B →	+0.539	+0.121	<.001	<.001	3	4
BRCA	TAOK3 →	+0.364	+0.155	.001	<.001	3	4
LUAD	HPGDS →	+0.728	+0.251	<.001	<.001	3	4
CCRCC	RXYLT1 →	+0.239	+0.184	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904376 vs GTF3C6P2 — BRCA

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