Negative regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOOK1, EPCAM, and MARVELD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOOK1 grouped by Negative regulation of protein localization to cell periphery-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HOOK1 →	+6.097	+0.440	<.001	.009	3	6
LUNG_NSCLC_LUSC	EPCAM →	+5.113	+0.465	.001	.002	3	6
LUNG_SCLC	MARVELD3 →	+2.040	+0.224	.001	.005	3	6
LUNG_SCLC	DEDD2 →	+1.301	+0.363	<.001	.001	3	6
LUNG_SCLC	SPINT1 →	+2.665	+0.221	.009	.006	3	6
LUNG_SCLC	CRTAP →	-2.275	-0.259	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOOK1 by Negative regulation of protein localization to cell periphery activity — BONE

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