Negative regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1B2, ABITRAM, and ZSWIM5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to cell periphery activity versus EEF1B2 in OVARY (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EEF1B2 →	-0.729	-0.280	<.001	.001	3	5
LUNG_SCLC	ABITRAM →	-0.607	-0.170	.005	.003	3	5
LUNG_SCLC	ZSWIM5 →	-1.566	-0.154	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	FAM117B →	-0.639	-0.313	<.001	<.001	3	5
BLOOD_Lymphoma	CYP27B1 →	-1.931	-0.278	<.001	.002	3	5
BONE	ATF4 →	-0.966	-0.311	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904376 vs EEF1B2 — OVARY

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