Regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3A, PRR3, and CTSD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell periphery activity versus MEX3A in BONE (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MEX3A →	-3.023	-0.274	<.001	<.001	3	9
BONE	PRR3 →	-0.977	-0.277	<.001	<.001	3	9
LUNG_NSCLC_LUSC	CTSD →	+2.048	+0.194	.002	.009	3	8
STOMACH	ANXA2 →	+2.313	+0.254	.008	.001	3	8
BONE	TPM1 →	+3.926	+0.303	.001	<.001	3	8
LARGE_INTESTINE	SH3TC2 →	+2.047	+0.246	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904375 vs MEX3A — BONE

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