Positive regulation of telomere maintenance via telomere lengthening

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomere maintenance via telomere lengthening pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIGD1AP14, HMBS, and APLP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere maintenance via telomere lengthening activity versus HIGD1AP14 in COAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HIGD1AP14 →	-0.538	-0.123	<.001	<.001	3	4
COAD	HMBS →	-0.331	-0.086	.004	<.001	3	4
GBM	APLP1 →	-0.537	-0.065	.005	.008	3	4
GBM	RASAL1 →	-1.069	-0.099	<.001	<.001	3	4
GBM	FBXO2 →	-1.118	-0.105	<.001	<.001	3	4
PDAC	RNA5SP319 →	-0.600	-0.129	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904358 vs HIGD1AP14 — COAD

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