Positive regulation of telomere maintenance via telomere lengthening

Across TCGA cell cohorts, RNA activity of the Positive regulation of telomere maintenance via telomere lengthening pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDCBP, IRF1, and EOGT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDCBP grouped by Positive regulation of telomere maintenance via telomere lengthening-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SDCBP →	-0.968	-0.231	.002	<.001	3	5
LUNG_SCLC	IRF1 →	+0.877	+0.156	.005	.008	3	4
LARGE_INTESTINE	EOGT →	+0.668	+0.113	.008	.008	2	5
BREAST	SCNN1D →	+0.848	+0.112	.003	.009	2	5
OVARY	PEPD →	-0.519	-0.193	.001	.002	3	3
OVARY	ARHGAP18 →	+1.348	+0.172	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDCBP by Positive regulation of telomere maintenance via telomere lengthening activity — SOFT_TISSUE

Explore this box plot interactively →