Positive regulation of telomere maintenance via telomere lengthening

Across TCGA cell cohorts, RNA activity of the Positive regulation of telomere maintenance via telomere lengthening pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TUBB4B, CCT2, and CCT4, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere maintenance via telomere lengthening activity versus TUBB4B in PANCREAS (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TUBB4B →	+2.288	+0.450	<.001	<.001	3	18
PANCREAS	CCT2 →	+2.168	+0.469	<.001	<.001	3	18
LUNG_NSCLC_LUSC	CCT4 →	+1.875	+0.419	<.001	<.001	3	18
LUNG_NSCLC_LUSC	CCT5 →	+1.700	+0.452	.001	<.001	3	18
LUNG_NSCLC_LUSC	CCT8 →	+2.025	+0.452	<.001	<.001	3	18
LIVER	CRK →	+1.662	+0.307	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904358 vs TUBB4B — PANCREAS

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