Negative regulation of telomere maintenance via telomere lengthening

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere maintenance via telomere lengthening pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1_S672, HCFC1, and SMC1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance via telomere lengthening activity versus TNKS1BP1_S672 in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNKS1BP1_S672 →	-0.688	-0.043	<.001	<.001	3	6
LSCC	HCFC1 →	+0.170	+0.050	<.001	<.001	3	6
LSCC	SMC1A →	+0.266	+0.047	<.001	<.001	3	5
PDAC	SNW1 →	+0.162	+0.031	<.001	<.001	3	5
LSCC	ZC3H18 →	+0.182	+0.035	<.001	.001	3	5
HNSC	CPSF3 →	+0.185	+0.053	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904357 vs TNKS1BP1_S672 — OV

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