Negative regulation of telomere maintenance via telomere lengthening

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere maintenance via telomere lengthening pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG1, TICRR, and MTFR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance via telomere lengthening activity versus SNHG1 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNHG1 →	+0.499	+0.679	.004	.004	3	5
BRCA	TICRR →	+0.700	+0.178	.001	.005	3	5
BRCA	MTFR2 →	+0.625	+0.166	.001	.002	3	5
BRCA	HROB →	+0.416	+0.130	.001	.002	3	5
BRCA	DDIAS →	+0.742	+0.164	.001	.002	3	5
BRCA	CDK1 →	+0.746	+0.190	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904357 vs SNHG1 — OV

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