Regulation of telomere maintenance via telomere lengthening

Across TCGA patient cohorts, RNA activity of the Regulation of telomere maintenance via telomere lengthening pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCC2, TNKS1BP1_S601, and ADNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance via telomere lengthening activity versus SMARCC2 in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMARCC2 →	+0.205	+0.063	.003	.001	3	6
UCEC	TNKS1BP1_S601 →	-0.523	-0.048	.001	.001	3	6
LSCC	ADNP →	+0.328	+0.040	.003	.004	3	6
HNSC	HCFC1 →	+0.179	+0.064	.002	.005	3	6
LSCC	ARID4B →	+0.273	+0.050	<.001	<.001	3	6
LSCC	SMC1A →	+0.240	+0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904356 vs SMARCC2 — UCEC

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