Positive regulation of telomere capping

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCQ, SNRPEP4, and NBPF22P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere capping activity versus PRKCQ in LSCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRKCQ →	+0.884	+0.189	<.001	.005	3	4
LSCC	SNRPEP4 →	+0.413	+0.163	.003	.003	3	3
HNSC	NBPF22P →	-0.931	-0.182	.001	.001	3	2
HNSC	AK3P5 →	+0.830	+0.236	<.001	<.001	3	2
HNSC	LYPD9P →	-0.383	-0.165	.002	.001	3	2
HNSC	FCGR2C →	+0.722	+0.188	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904355 vs PRKCQ — LSCC

Explore this scatter interactively →