Positive regulation of telomere capping

Across TCGA cell cohorts, RNA activity of the Positive regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPECC1L, WDR61, and ARL4D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPECC1L grouped by Positive regulation of telomere capping-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPECC1L →	+0.717	+0.704	<.001	.005	3	5
LARGE_INTESTINE	WDR61 →	-0.383	-0.733	<.001	.006	2	5
STOMACH	ARL4D →	+2.568	+0.929	<.001	.006	3	4
SOFT_TISSUE	WEE1 →	+1.099	+0.400	<.001	<.001	3	4
BLOOD_Leukemia	POU5F1 →	+0.288	+1.061	<.001	<.001	3	4
BONE	RPL36AL →	-0.726	-1.204	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPECC1L by Positive regulation of telomere capping activity — STOMACH

Explore this box plot interactively →