Negative regulation of telomere capping

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere capping pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERCC4, THUMPD1, and PARN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere capping activity versus ERCC4 in LSCC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ERCC4 →	+0.212	+0.040	<.001	<.001	3	6
BRCA	THUMPD1 →	+0.418	+0.035	<.001	<.001	3	5
LSCC	PARN →	+0.250	+0.042	<.001	<.001	3	5
LSCC	TERF2 →	+0.263	+0.046	.002	.001	3	4
HNSC	TRPS1_S1081 →	-0.479	-0.043	.001	.002	3	4
UCEC	EPM2AIP1 →	+0.454	+0.042	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904354 vs ERCC4 — LSCC

Explore this scatter interactively →