Negative regulation of telomere capping

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX35, FCGR1CP, and RPL18AP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere capping activity versus DHX35 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHX35 →	+0.611	+0.310	<.001	.009	3	4
GBM	FCGR1CP →	-0.723	-0.530	.003	.003	3	4
CCRCC	RPL18AP7 →	+0.507	+0.588	<.001	.003	3	4
GBM	C19orf44 →	+0.433	+0.651	.002	.001	3	3
GBM	BTK →	-0.462	-0.413	.002	.004	3	3
GBM	DOCK8 →	-0.593	-0.720	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904354 vs DHX35 — HNSC

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