Negative regulation of telomere capping

Across TCGA cell cohorts, RNA activity of the Negative regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODF3B, LSM14B, and DHX9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere capping activity versus ODF3B in LIVER (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ODF3B →	-1.627	-1.443	.009	.007	3	4
BREAST	LSM14B →	+0.731	+0.879	<.001	.001	3	4
PANCREAS	DHX9 →	+0.565	+0.964	.005	.002	2	5
URINARY_TRACT	HIBCH →	+1.285	+1.508	.003	.002	3	4
OESOPHAGUS	VWA8 →	+0.962	+1.322	.002	<.001	3	4
OESOPHAGUS	APPL1 →	+0.767	+0.958	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904354 vs ODF3B — LIVER

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