Regulation of telomere capping

Across TCGA patient cohorts, RNA activity of the Regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR25, E2F3, and RAD17P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere capping activity versus MIR25 in PDAC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MIR25 →	+0.515	+0.153	.005	.004	3	4
HNSC	E2F3 →	+0.356	+0.146	.006	.006	3	4
UCEC	RAD17P1 →	-0.702	-0.272	.001	<.001	3	4
LUAD	ZC2HC1B →	+0.116	+0.130	.009	.005	3	3
LUAD	RNF114 →	+0.224	+0.123	.007	<.001	3	3
LUAD	KMT5C →	+0.399	+0.170	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904353 vs MIR25 — PDAC

Explore this scatter interactively →