Regulation of telomere capping

Across TCGA cell cohorts, RNA activity of the Regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, CDYL, and TGIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Regulation of telomere capping-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDKN1A →	+2.307	+0.450	<.001	.002	3	5
KIDNEY	CDYL →	+0.593	+0.848	.002	.005	3	3
KIDNEY	TGIF1 →	+0.523	+0.897	.006	.002	3	3
KIDNEY	RABL6 →	+1.164	+1.363	<.001	.001	3	3
KIDNEY	WHRN →	+1.146	+0.982	.003	.009	3	3
BREAST	TUBGCP2 →	+0.736	+0.413	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Regulation of telomere capping activity — LARGE_INTESTINE

Explore this box plot interactively →