Negative regulation of protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP13A2, USP8, and FURIN, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein catabolic process in the vacuole activity versus ATP13A2 in KIDNEY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ATP13A2 →	+1.392	+0.180	<.001	<.001	3	19
BREAST	USP8 →	+0.682	+0.120	.002	<.001	3	11
BREAST	FURIN →	+1.095	+0.143	.002	<.001	3	11
LARGE_INTESTINE	TMOD3 →	+0.710	+0.130	<.001	<.001	3	10
BONE	MGAT3 →	-1.455	-0.129	<.001	<.001	3	9
BLOOD_Leukemia	ABHD2 →	+1.216	+0.141	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904351 vs ATP13A2 — KIDNEY

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