Positive regulation of gastro-intestinal system smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of gastro-intestinal system smooth muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIP4K2A, SEPTIN1_S206, and CD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gastro-intestinal system smooth muscle contraction activity versus PIP4K2A in LSCC (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIP4K2A →	+0.338	+0.093	<.001	<.001	3	6
LSCC	SEPTIN1_S206 →	+0.676	+0.077	<.001	<.001	3	6
LSCC	CD4 →	+0.457	+0.091	<.001	<.001	3	6
LSCC	GIMAP8 →	+0.483	+0.101	<.001	<.001	3	6
LSCC	GRAP2 →	+0.510	+0.104	<.001	<.001	3	6
LSCC	HMGB3 →	-0.567	-0.101	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904306 vs PIP4K2A — LSCC

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