Positive regulation of gastro-intestinal system smooth muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of gastro-intestinal system smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRS2P2, LRRC74A, and RNU6-378P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gastro-intestinal system smooth muscle contraction activity versus MRS2P2 in UCEC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRS2P2 →	+0.985	+0.610	<.001	<.001	3	4
CCRCC	LRRC74A →	+0.510	+0.291	<.001	.002	2	4
GBM	RNU6-378P →	+0.731	+0.247	<.001	<.001	3	3
LSCC	SNORD56B →	+0.622	+0.582	.006	.002	3	3
LSCC	ROR1-AS1 →	+0.392	+0.556	.003	.008	3	3
GBM	RN7SL231P →	+0.405	+0.159	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904306 vs MRS2P2 — UCEC

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