Positive regulation of gastro-intestinal system smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of gastro-intestinal system smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMPK2, DNMT3A, and CLCN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMPK2 grouped by Positive regulation of gastro-intestinal system smooth muscle contraction-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CMPK2 →	+2.420	+1.995	.003	.002	3	4
SKIN	DNMT3A →	+0.674	+1.263	.001	<.001	3	4
BREAST	CLCN4 →	+1.079	+0.956	.001	<.001	3	4
SOFT_TISSUE	FAM149B1 →	-0.431	-1.052	.003	<.001	3	3
URINARY_TRACT	CHST10 →	-2.692	-1.871	.004	<.001	3	3
URINARY_TRACT	PLCD4 →	-0.721	-1.562	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMPK2 by Positive regulation of gastro-intestinal system smooth muscle contraction activity — URINARY_TRACT

Explore this box plot interactively →