Positive regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JTB, FASTKD5, and STXBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JTB grouped by Positive regulation of ERAD pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	JTB →	-0.484	-0.809	.001	.005	3	4
LUNG_SCLC	FASTKD5 →	-0.796	-1.496	.001	<.001	3	4
LUNG_SCLC	STXBP1 →	-2.309	-1.368	.003	.008	3	4
LUNG_SCLC	GNG4 →	-4.276	-1.650	<.001	<.001	3	4
LUNG_SCLC	ZDHHC11B →	-1.993	-0.926	<.001	.009	3	4
LUNG_NSCLC_LUSC	ILF3 →	-0.758	-1.637	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JTB by Positive regulation of ERAD pathway activity — CNS

Explore this box plot interactively →