Positive regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPKAPK3, CORO1C, and CLIC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ERAD pathway activity versus MAPKAPK3 in OVARY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAPKAPK3 →	+1.211	+0.346	.006	<.001	3	6
LIVER	CORO1C →	+1.234	+0.359	.008	<.001	3	6
LIVER	CLIC1 →	+1.304	+0.253	.001	.003	3	6
LUNG_NSCLC_LUAD	CPOX →	+0.851	+0.267	.004	<.001	3	6
BLOOD_Lymphoma	HPCAL1 →	+1.733	+0.141	.001	.009	3	5
OVARY	ST14 →	-4.477	-0.336	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904294 vs MAPKAPK3 — OVARY

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