Positive regulation of TORC1 signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of TORC1 signaling pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P4HB, FAM122A, and ZNF358, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P4HB grouped by Positive regulation of TORC1 signaling-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	P4HB →	+0.811	+0.240	<.001	.001	3	4
LUNG_NSCLC_LUAD	FAM122A →	-0.412	-0.117	.006	.007	3	4
LUNG_NSCLC_LUAD	ZNF358 →	-0.705	-0.081	.001	.009	3	4
LARGE_INTESTINE	EID2 →	-0.566	-0.150	.002	.002	3	4
BLOOD_Leukemia	GCDH →	-0.732	-0.127	.007	.004	3	3
BLOOD_Leukemia	ZNF230 →	+0.854	+0.148	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P4HB by Positive regulation of TORC1 signaling activity — URINARY_TRACT

Explore this box plot interactively →