Positive regulation of TORC1 signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of TORC1 signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC8A3, DNMT3A, and H4C9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC8A3 grouped by Positive regulation of TORC1 signaling-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC8A3 →	+0.261	+0.089	.005	.003	3	4
BLOOD_Lymphoma	DNMT3A →	-0.177	-0.084	.006	.002	3	4
CNS	H4C9 →	+0.162	+0.049	<.001	<.001	3	4
LARGE_INTESTINE	NCOR1 →	+0.180	+0.056	.004	<.001	3	4
BLOOD_Lymphoma	PARP16 →	+0.205	+0.097	.002	.004	3	4
SKIN	MRPS12 →	-0.236	-0.058	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC8A3 by Positive regulation of TORC1 signaling activity — SOFT_TISSUE

Explore this box plot interactively →